Akademik Veri Yönetim Sistemi
Dillioğlugil M. Ö., Maral Kır H. (Yürütücü), Eraldemir F. C.
Diğer Resmi Kurumlarca Desteklenen Proje, 2003 - 2004
Abstract
Background: Excessive generation of reactive oxygen
species (ROS) contributes to the process of progressive
renal injury in a variety of clinical and experimental renal
diseases. The present study was designed to test the hypothesis that treatment with vitamins decreases renal
injury in chronic renal failure (CRF). Methods: Forty male
Sprague-Dawley rats were divided into 5 groups: group
1, control; group 2, 5/6 nephrectomy (CRF); other groups
5/6 nephrectomy and injected vitamins (E, A, D). After 8
weeks, urea, creatinine and renal tissue malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels
and superoxide dismutase (SOD) activities were determined. Results: Renal tissue MDA levels were significantly lower in the control and Vit E groups compared to
that of the CRF, Vit A and Vit D groups. GSH levels were
signifi cantly higher in the control group compared to
that of other groups. However, GSH levels were signifi -
cantly lower in the control group than those in the other
groups. SOD activities of the control group were significantly higher than those in the other groups. SOD activities were signifi cantly decreased in the Vit E group
compared to the Vit A and Vit D groups. Tissue NO levels
of control group were signifi cantly increased compared
to the other groups. Conclusion: According to this study,
Vit E may at least in part prevent tissue injury by acting
as a free radical scavenger.
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