Nitric oxide in gingival crevicular fluid and nitric oxide synthase expression in the gingiva of patients with sickle cell disease


Guzeldemir E., Toygar H. U. , Bal N., Anarat R., Boga C.

TURKISH JOURNAL OF HEMATOLOGY, vol.28, no.2, pp.115-124, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.5152/tjh.2011.27
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-124
  • Keywords: Sickle cell disease, nitric oxide, nitric oxide synthase, gingival crevicular fluid, gingiva, PERIODONTAL-DISEASE, REPERFUSION INJURY, PORPHYROMONAS-GINGIVALIS, L-ARGININE, MICE, METABOLITES, CRISIS, TISSUE, ISCHEMIA, ANEMIA
  • Kocaeli University Affiliated: Yes

Abstract

Objective: This study aimed to biochemically measure the production of nitric oxide in gingival crevicular fluid and immunohistochemically measure the expression of inducible nitric oxide synthase in the gingiva of patients with sickle cell disease. Additionally, we aimed to obtain insight into the immunopathology of sickle cell disease by comparing inducible nitric oxide synthase levels in patients with sickle cell disease and controls using gingiva and gingival crevicular fluid.