Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study

Rencber S. H., Ozbek S., Eraldemir C., Sezer Z., Kum T., Ceylan S., ...Daha Fazla

JOURNAL OF OVARIAN RESEARCH, cilt.11, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1186/s13048-018-0427-7
  • Dergi Adı: JOURNAL OF OVARIAN RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Dehydroepiandrosterone, Resveratrol, Metformin, Polycystic ovary syndrome, Oxidative stress, Inflammation, ACTIVATED PROTEIN-KINASE, THECA-INTERSTITIAL CELLS, ANTI-MULLERIAN HORMONE, OXIDATIVE STRESS, INSULIN-RESISTANCE, GRANULOSA-CELLS, FEMALE RATS, APOPTOSIS, INFLAMMATION, WOMEN
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background: PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate the potential therapeutic effects of combined therapy of resveratrol and metformin on polycystic ovaries via SIRT1 and AMPK activation.