Synthesis and characterization of novel quatemized 2, 3-(diethylmethylamino)phenoxy tetrasubstituted Indium and Gallium phthalocyanines and comparison of their antimicrobial and antioxidant properties with different phthalocyanines


ŞAKİ N. , Akin M., Atsay A., Pekbelgin Karaoğlu H. R. , Koçak M.

INORGANIC CHEMISTRY COMMUNICATIONS, cilt.95, ss.122-129, 2018 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 95
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.inoche.2018.07.010
  • Dergi Adı: INORGANIC CHEMISTRY COMMUNICATIONS
  • Sayfa Sayıları: ss.122-129

Özet

In this work, we describe the synthesis and characterization of tetra-substituted 2,9(10),16(17),23(24)-tetrakis-[3-(diethylmethylamino)phenoxy) phthalocyaninatochlorogallium (III) tetraiodide and 2,9(10),16(17),23(24)-tetrakis-[3-(diethylmethylamino)phenoxy) phthalocyaninatochloroindium (III) tetraiodide and comparision of their antioxidant and antimicrobial activities with previously synthesized metallo- or metal-free octa-substituted phthalocyanines bearing diethylaminophenoxy groups at peripheral positions. Antioxidant activities of the compounds were investigated by using DPPH free radical scavenging assay, beta-carotene/linoleic acid bleaching assay and reducing power assay and no significant difference was observed between metal-containing and metal-free phthalocyanine compounds. Disc diffusion and macro dilution methods were used to determine the antimicrobial activities of the PCs on Gram-negative and Gram-positive bacteria and newly synthesized tetra-cationic gallium (PC6) and indium (PC7) phthalocyanines showed antimicrobial activity against all tested microorganisms. Antibacterial activity of neutral compounds was considerably lower or even negligible than that of cationic ones.