This study is part of a research program within the framework of NATO Project 977231 "Seismic Assessment and Rehabilitation of Existing Buildings" led by METU. A new seismic retrofitting method by using CFRP cross overlays is experimentally investigated. Five specimens were tested to highlight the effect of brick infill and epoxy bonded CFRP overlays on the strength and behavior of poorly detailed reinforced concrete frames. The main deficiencies of the one-third scale one-bay, two-story frames tested were low concrete strength, insufficient column lap splice length, poor confinement, and inadequate anchorage length of beam bottom reinforcement. In all specimens beams were stronger than columns and no joint shear reinforcement was used.