Continuous Renal Replacement Therapy for Treatment of Severe Attacks of Inborn Errors of Metabolism

Yetimakman A. F. , Kesici S., Tanyildiz M., BAYRAKCİ B.

JOURNAL OF PEDIATRIC INTENSIVE CARE, vol.8, no.3, pp.164-169, 2019 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.1055/s-0039-1683991
  • Page Numbers: pp.164-169
  • Keywords: continuous renal replacement therapy, inborn errors of metabolism, acute metabolic crises, CONTINUOUS VENOVENOUS HEMOFILTRATION, ACUTE MANAGEMENT, CHILDREN, DIALYSIS, HYPERAMMONEMIA, HEMODIALYSIS, ACIDEMIA, SURVIVAL, BRAIN


Severe metabolic crises in children with inborn errors of metabolism can result in mortality or severe morbidities where continuous renal replacement therapy (CRRT) can be lifesaving. Clinical data, the pediatric risk of mortality (PRISM) scores calculated in the first 24 hours, and pediatric logistic organ dysfunction (PELOD) scores calculated in the last 24 hours before CRRT, were studied. Overall, CRRT was successful in restoring metabolic balance in 72% of patients. PELOD scores before CRRT were lower in survivors (p = 0.02). Despite numerous comorbid factors, CRRT can be used effectively in management of metabolic crises. Early intervention with this therapy before occurrence of complications must be targeted.