Effect of pentoxifylline on healing of segmental bone defects and angiogenesis

Cakmak G., Sahin M. S., Ozdemir B. H., Karadeniz E.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.49, no.6, pp.676-682, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.3944/aott.2015.15.0158
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.676-682
  • Keywords: Bone graft, bone healing, cortical defect, pentoxifylline, ISCHEMIA-REPERFUSION INJURY, SPINAL-CORD ISCHEMIA, PROTEIN-KINASE-A, ENDOTHELIAL-CELLS, PARATHYROID-HORMONE, NEUTROPHIL MIGRATION, OVARIECTOMIZED RATS, SKELETAL-MUSCLE, RABBITS, MICE
  • Kocaeli University Affiliated: No

Abstract

Objective: The aim of this study was to determine the effect of pentoxifylline (PTX) on angiogenesis and the healing of a critical-sized segmental defect of the radius diaphysis in a rat model, using radiological and histological grading systems.