The protective effect of metformin in scopolamine-induced learning and memory impairment in rats

Aksoz E., Gocmez S. S., Demirtaş Şahin T., Aksit D., Aksit H., Utkan T.

PHARMACOLOGICAL REPORTS, cilt.71, ss.818-825, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.pharep.2019.04.015
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.818-825
  • Anahtar Kelimeler: Metformin, Memory, Scopolamine, Antioxidant, pAMPK, CREB PHOSPHORYLATION, ALZHEIMERS-DISEASE, NEUROGENESIS, HIPPOCAMPUS, COGNITION, MARKER, DRUG
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background: Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. One of the most commonly prescribed oral antidiabetic drug, metformin, has been shown to have beneficial effects on restoring impaired cognitive function. In the present study, we investigated the effects of metformin on spatial memory in terms of alleviating scopolamine-induced learning and memory impairments in rats by using the Morris water maze (MWM) test and the modified elevated plus-maze (mEPM) test. Furthermore, we investigated the possible mechanisms of action of metformin in preventing cognitive dysfunction.