Exenatide Alters Gene Expression of Neural Cell Adhesion Molecule (NCAM), In-tercellular Cell Adhesion Molecule (ICAM), and Vascular Cell Adhesion Molecule (VCAM) in the Hippocampus of Type 2 Diabetic Model Mice

Gumuslu E., ÇİNE N., Gokbayrak M. E., MUTLU O., Celikyurt I. K., ULAK G.

MEDICAL SCIENCE MONITOR, vol.22, pp.2664-2669, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2016
  • Doi Number: 10.12659/msm.897401
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2664-2669
  • Keywords: Diabetes Mellitus, Genetic Association Studies, Mice, Inbred BALB C, ENDOTHELIAL-CELLS, PEPTIDE-1 RECEPTOR, CEREBRAL-ISCHEMIA, UP-REGULATION, N-CAM, PATHWAY, RAT, MELLITUS, GLP-1, ACID
  • Kocaeli University Affiliated: Yes

Abstract

Background: Glucagon-like peptide-1 (GLP-1), a potent and selective agonist for the GLP-1 receptor, ameliorates the symptoms of diabetes through stimulation of insulin secretion. Exenatide is a potent and selective agonist for the GLP-1 receptor. Cell adhesion molecules are members of the immunoglobulin superfamily and are involved in synaptic rearrangements in the mature brain.