Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses

Nagy, Balint; SAVLI, HAKAN; Molvarec, Attila; Varkonyi, Tibor; Rigo, Barbara; Hupuczi, Petronella; Rigo, Janos

doi:10.1016/j.cca.2007.12.003

Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses

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Nagy B., SAVLI H., Molvarec A., Varkonyi T., Rigo B., Hupuczi P., ...More

CLINICA CHIMICA ACTA, vol.389, pp.126-131, 2008 (SCI-Expanded)

Publication Type: Article / Article
Volume: 389
Publication Date: 2008
Doi Number: 10.1016/j.cca.2007.12.003
Journal Name: CLINICA CHIMICA ACTA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.126-131
Kocaeli University Affiliated: Yes

Abstract

Background: The vascular endothelial growth factor (VEGF) has a critical role in vasculogenesis and vascular permeability in several diseases including preeclampsia. There are at least 30 single nucleotide polymorphic (SNP) places on this gene. VEGF G+405C, C-2578A and C-460T SNPs are known to be related to VEGF production. VEGF polymorphisms were studied in preeclampsia, but not in HELLP syndrome. Therefore, we decided to determine the allele and genotype frequencies of VEGF G+405C, C-460T and C-2578A SNPs in healthy pregnant women and HELLP syndrome patients.