Microarray-based gene expression analysis of an animal model for closed head injury


ÇOLAK T. , Cine N. , BAMAÇ B. , Kurtas O. , OZBEK A., BICER U., ...More

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.43, no.8, pp.1264-1270, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 8
  • Publication Date: 2012
  • Doi Number: 10.1016/j.injury.2012.01.021
  • Title of Journal : INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Page Numbers: pp.1264-1270
  • Keywords: Rats, Craniocerebral trauma, Microarray, TRAUMATIC BRAIN-INJURY, C1Q FAMILY PROTEINS, MATRIX METALLOPROTEINASES, ENDOTHELIAL-CELLS, GROWTH-FACTOR, ANGIOGENESIS, ISCHEMIA, DEATH, PATHOPHYSIOLOGY, MECHANISMS

Abstract

Objective: Traumatic brain injury (TBI) is a major cause of death and disability in both children and the elderly. Mortality from TBI is said account for 1-2% of all deaths. One-third to one-half of all traumatic deaths is due to head injury. Of those who survive, the majority is left with significant disabilities, including 3% who remain in a vegetative state and only approximately 30% who make a good recovery. Microarray studies and other genomic techniques facilitate the discovery of new targets for the treatment of diseases, which aids in drug development, immunotherapeutics and gene therapy. Gene expression profiling or microarray analysis enables the measurement of thousands of genes in a single RNA sample.