Akademik Veri Yönetim Sistemi
Journal of Medicine, Physiology and Biophysics, cilt.68, ss.19-29, 2020 (Hakemli Dergi)
In this study, we aimed to compare DNA fragmentation ratios, centrosomal protein concentrations (centrin and
tubulin) and numerical chromosomal abnormalities between four groups including asthenozoospermia,
teratozoospermia, oligoasthenozoospermia and normozoospermia patients, and to emphasize the necessity of
investigating genetic and protein content of the spermatozoa also in patients with a semen analysis within normal
reference range. Evaluation of semen analysis of the patients was performed based on WHO 2010 criteria. As a
result of the statistical analysis, it was observed that the sperm DNA fragmentation rate in the normozoospermia
group (6.50 ± 3.46%) was significantly lower than those in the teratozoospermia (19.69 ± 9.86%) and
oligoasthenoteratozoospermia group (32.47± 14.13%) (p<0.001). For centrin and tubulin proteins, highest
concentrations were observed in normozospermia group (p<0.05). When incidence of numerical abnormalities
were compared between four groups, it was found that there were statistically significant differences between
groups in terms of nullisomies X, Y and 13, and 21 (p<0.05). In conclusion, we suggest that abnormalities in
semen parameters seem to be associated with chromosomal abnormalities; and sperm aneuploidy rate is also at a
considerable level even in normozoospermic patients.