Cytokine responses to symbiotic and lactoferrin combination in very low birth weight neonates: a randomized control trial

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Pehlevan Ö., Benzer D., Gursoy T., ÇETİN E., Karatekin G., Ovali F.

ARCHIVOS ARGENTINOS DE PEDIATRIA, vol.118, no.1, 2020 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.5546/aap.2020.eng.e8
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Keywords: cytokines, lactoferrin, necrotizing enterocolitis, prebiotics, probiotics, NECROTIZING ENTEROCOLITIS, T-CELLS, IN-VITRO, PROBIOTICS, INFANTS, INTERLEUKIN-10, SYNBIOTICS, PREBIOTICS, PATHOGENESIS
  • Kocaeli University Affiliated: Yes


Introduction. Probiotics and prebiotics, which are multifunctional agents, have potential benefits in chronic mucosal inflammation, including the prevention of necrotizing enterocolitis. However, the mechanisms and the results of these immunomodulatory effects are not clear. This study aimed to investigate the cytokine response to the combination of Lactobacillus and Bifidobacterium together with fructo- and galacto-oligosaccharides (symbiotic) and lactoferrin in very low birth weight neonates.