Gene polymorphisms of endothelial nitric oxide synthase enzyme associated with pulmonary hypertension in patients with COPD

Yildiz P., Oflaz H., Cine N., Erginel-Unaltuna N., Erzengin F., Yilmaz V.

RESPIRATORY MEDICINE, vol.97, no.12, pp.1282-1288, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 97 Issue: 12
  • Publication Date: 2003
  • Doi Number: 10.1016/j.rmed.2003.06.001
  • Journal Name: RESPIRATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1282-1288
  • Kocaeli University Affiliated: Yes

Abstract

In this cross-sectional controlled study, we aimed to investigate the rote of polymorphisms of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes on pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD). Forty-two (41 mate, 1 female, mean age: 62 +/- 7 years) COPD patients and 40 (all mate, mean age: 60 +/- 8 years) healthy controls were included. Respiratory function tests, arterial blood gases, and echocardiographic examinations were performed. ACE and eNOS genotypes were determined using PCR.