In this study, it was aimed to determine the endocrine disrupting chemicals (EDCs) in the effluent of the conventional treatment plant of an organized industrial zone (OIZ) where different industries produce together and to examine the treatability of these chemicals by ozone-based oxidation methods. Bisphenol A (BPA), diclofenac (DCF), triclosan (TCS), polyaromatic hydrocarbons (PAH), and polychlorinated biphenyls (PCB) were determined as target EDCs in the effluents. The efficiencies of the processes were evaluated over chemical oxygen demand (COD), total organic carbon (TOC), and active substance parameters. The high mineralization and active substance removals were achieved in the photocatalytic ozone (O3/UVC/ZnO) process at 5 ppm ozone dose. In O3/UVC/ZnO processes, 82% COD and 81% TOC removal efficiencies were achieved. Most of the target pollutants were removed at the rate of 30–95% with this process. Phytotoxicity test was carried using Lepidium sativum after treatment. It was determined that the O3/UVC/ZnO process did not have a toxic effect on the growth of the Lepidum sativum plant. The cost evaluations were made by energy consumption of the processes. The E EO of O3/UVC/ZnO process based on the COD and TOC removals were calculated as 321 kWh/m3 and 331 kWh/m3, respectively. The cost values of this process were determined respectively as 25.1 €/m3 and 25.9 €/m3. O3/UVC/ZnO process can be considered as an alternative for the treatment of OIZ wastewater.