Akademik Veri Yönetim Sistemi
24th Biennial International Congress on Thrombosis / EMLTD Congress, İstanbul, Türkiye, 4 - 07 Mayıs 2016, cilt.141, (Özet Bildiri)
Background: Perioperative myocardial infarction is a devastating compli- cation of surgical procedures of abdominal aorta. Ischemia/ reperfusion via clamping and declamping of the aorta leads to remote organ damage and the major part of this damage occurs upon reperfusion via oxygen free radicals. An antiplatelet agent, Cilostazol is analyzed in this study for its cardio protective effect following abdominal aota ischemia/reperfusion model in rats.
Methods: Twenty-eight male Spraque-Dawley rats were randomized as sham group (I/R, n=8), control group (n=8), and I/R+Cilostazol (n=8, 100mg/ kg orally administered before ischemia) groups. Ischemia and reperfusion was induced by clamping the infrarenal aorta for 2 hours and declamping for reperfusion for 4 hours. Myocardial tissue assays were performed for lipid peroxidation product malondealdehyde (MDA) and Glutathione Reductase (GR) and Glutathione Peroxidase (GPx) levels were also studied. Myocardial tissues were also examined histopathologically under light microscopy.
Results: Cilostazol attenuated myocardial cell damage occurred by downregulating the level of MDA and upregulating the levels of GPX and GR. These results are confirmed also with the histopathological results.
Conclusions: These results suggested that one dose oral administration of Cilostazol effectively ameliorates the ischemia/reperfusion induced oxidative damage of myocardial tissue via its antioxidant and anti-
inflammatory potential.