Immunocytochemistry of neuron specific enolase (NSE) in the rat brain after single and repeated epileptic seizures

Yardimoglu M., Ilbay G., DALÇIK C., DALÇIK H., ŞAHİN D., ATEŞ N.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.118, no.7, pp.981-993, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118 Issue: 7
  • Publication Date: 2008
  • Doi Number: 10.1080/00207450701769232
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.981-993
  • Keywords: epileptic seizure, neuron specific enolase, nissl, pentylenetetrazol, rat brain, TEMPORAL-LOBE EPILEPSY, CEREBROSPINAL-FLUID, S-100 PROTEIN, KAINIC ACID, DAMAGE, MARKER, INCREASES, HIPPOCAMPUS, EXPRESSION, AUTOPSIES
  • Kocaeli University Affiliated: Yes


The aim of this study was to investigate neuron-specific enolase (NSE) immunoreactivity of the different brain regions after pentylenetetrazol (PTZ)- induced epileptic seizures in rats. Light microscopic examinations provided evidences for changes of neuronal activity after single and repeated seizures. The number of NSE (+) cells was well correlated with Nissl staining. The results suggest that NSE immunoreactivity may be a valuable marker for determination of the number of metabolically active neurons in different brain regions after single and repeated experimental seizures.