Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction

Ozbek, Emin; Adaş, Gokhan; Otunctemur, Alper; Duruksu, GÖKHAN; Koç, Bora; Polat, Emre; Sarvan, Ahu; Okcu, Alparslan; Kamalı, Gulcin; Subaşı, Cansu; Karaöz, Erdal

doi:10.6002/ect.2014.0080

Role of Mesenchymal Stem Cells Transfected With Vascular Endothelial Growth Factor in Maintaining Renal Structure and Function in Rats with Unilateral Ureteral Obstruction

Ozbek E., Adaş G., Otunctemur A., Duruksu G., Koç B., Polat E. C., ...Daha Fazla

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.13, ss.262-272, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13
Basım Tarihi: 2015
Doi Numarası: 10.6002/ect.2014.0080
Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.262-272
Anahtar Kelimeler: Epithelial-mesenchymal transition, Renal injury, Obstructive nephropathy, Ureter obstruction, BONE-MARROW, INTERSTITIAL FIBROSIS, OXIDATIVE STRESS, STROMAL CELLS, INJURY, MODEL, VEGF, ANGIOGENESIS, KIDNEY, GLOMERULONEPHRITIS
Kocaeli Üniversitesi Adresli: Evet

Özet

Objectives: Mesenchymal stem cells hold promise for renal disease treatment. Vascular endothelial growth factor may heal tubule-interstitial fibrosis in unilateral ureteral obstruction by inhibiting epithelial-mesenchymal transition. We investigated the protective effect of vascular endothelial growth factor in transfected mesenchymal stem cells in unilateral ureteral obstruction-induced renal injury in rats.