The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease

GEZER E. , Cetinarslan B. , SELEK A. , CANTÜRK Z. , SÖZEN M. , ELEN Ö. , ...More

ENDOCRINE RESEARCH, vol.46, pp.92-98, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46
  • Publication Date: 2021
  • Doi Number: 10.1080/07435800.2021.1883056
  • Title of Journal : ENDOCRINE RESEARCH
  • Page Numbers: pp.92-98


Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).