The association between insulin-like growth factor 1 levels within reference range and early postoperative remission rate in patients with Cushing's disease

GEZER E., Cetinarslan B., SELEK A., CANTÜRK Z., SÖZEN M., ELEN Ö., ...More

ENDOCRINE RESEARCH, vol.46, no.3, pp.92-98, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1080/07435800.2021.1883056
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.92-98
  • Keywords: Cushing's Disease, insulin-like growth factor 1, early postoperative remission
  • Kocaeli University Affiliated: Yes


Introduction: The relationship between growth hormone (GH)/insulin-like growth factor 1 (IGF-1) and glucocorticoids (GC) was examined in various studies. Long-term GC treatment was shown to decrease GH concentration and, interestingly, to increase IGF-1 concentration. We performed a retrospective study in order to examine how preoperative IGF-1 concentrations vary within the reference range and if tertiles of age- and sex-adjusted normal IGF-1 are predictive for early postoperative remission in the patients with Cushing's Disease (CD).