Effects of chronic ethanol treatment on glial fibrillary acidic protein expression in adult rat optic nerve: an immunocytochemical study

Gonca S. , Filiz S. , Dalçık C., Yardimoglu M. , Dalçık H., Yazır Y. , ...More

CELL BIOLOGY INTERNATIONAL, vol.29, no.2, pp.169-172, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1016/j.cellbi.2004.11.020
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.169-172


Glial fibrillary acidic protein (GFAP) is used as a marker of astrocyte response to various central nervous system injuries. In the present study, the effects of chronic ethanol administration on GFAP immunoreactivity were evaluated in astrocytes of the adult optic nerve head. The results demonstrated that ethanol exposure significantly and dramatically increases GFAP immunoreactivity and the number of immunoreactive astrocytes (p<0.001). In addition, GFAP immunoreactive cells in the optic nerve showed extensive hypertrophy (p<0.001). (C) 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.