The diagnostic importance of pathogenic variants and variant coexistence determined by NGS-based liquid biopsy approach in patients with lung adenocarcinoma

Çine N., Sen E. A., Demir G., Gokbayrak M., Guzdolu E., Sertdemir N., ...More

MOLECULAR AND CELLULAR PROBES, vol.64, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64
  • Publication Date: 2022
  • Doi Number: 10.1016/j.mcp.2022.101819
  • Journal Name: MOLECULAR AND CELLULAR PROBES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: Cell free DNA, Liquid biopsy, Lung adenocarsinoma, NGS, TP53, EGFR, MET, ALK, PIK3CA, MAP2K, CIRCULATING TUMOR DNA, P53 MUTATIONS, MUTAGENIC SIGNATURE, TOBACCO-SMOKE, K-RAS, CANCER, PATTERNS, LESSONS
  • Kocaeli University Affiliated: Yes

Abstract

Backround: Identification of driver mutations and rapid detection of genetic changes in lung cancer are critical in the management of the disease. Genetic structures of tumor tissues tend to change constantly and the possibility of emergence of new pathogenic variants that will create resistance to treatment. Liquid biopsy analysis has been one of the most effective approaches used to monitor and identify individual genetic changes.