Antinociception induced by verapamil and chloramphenicol in mice

Yıldıran G., Ulak G. , Utkan G. , Göldeli E., Gacar N., Erden F.

BIOLOGY OF THE NEONATE, vol.72, pp.28-31, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72
  • Publication Date: 1997
  • Doi Number: 10.1159/000244463
  • Title of Journal : BIOLOGY OF THE NEONATE
  • Page Numbers: pp.28-31


The analgesic effects of verapamil, a calcium channel blocker, and chloramphenicol, a phenicolated antibiotic, were compared using the test of acetic-acid-induced writhing and the hot-plate test in mice. The results suggest that both drugs have antinociceptive properties comparable to salicylate analgesia. No significant difference was found between verapamil- and chloramphenicol-induced analgesia (p < 0.05).