Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens

Tanyeri M. H., Buyukokuroglu M. E., Tanyeri P., Mutlu O., Akar F., Ulak G., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.49, ss.1561-1567, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s11255-017-1640-9
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1561-1567
  • Anahtar Kelimeler: Aripiprazole, Clozapine, Haloperidol, Organ bath, SEXUAL DYSFUNCTION, ANTIPSYCHOTIC-DRUGS, COPULATORY-BEHAVIOR, RAT, SCHIZOPHRENIA, FLUOXETINE, EJACULATION, SEROTONIN, ANTIDEPRESSANT, CONTRACTILITY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.