Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens


Tanyeri M. H. , Buyukokuroglu M. E. , Tanyeri P., Mutlu O. , Akar F. , Ulak G. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.49, pp.1561-1567, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49
  • Publication Date: 2017
  • Doi Number: 10.1007/s11255-017-1640-9
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.1561-1567

Abstract

Sexual dysfunction is a common condition in patients taking antipsychotics and is the most bothersome symptom and adverse drug effect, resulting in a negative effect on treatment compliance. Pharmacology research into human ejeculatory disorders is limited to clinical studies with registered drugs affecting the ejaculation process; therefore, animal research has become the need. We aimed to investigate the effects of haloperidol, clozapine and aripiprazole on serotonin, noradrenaline, adenosine triphosphate (ATP) and potassium chloride (KCl)-induced contractions of the vas deferens in order to evaluate the effect of haloperidol, clozapine and aripiprazole on the contraction of the vas deferens.