Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis.


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Schaefer A. S. , Bochenek G., Jochens A., Ellinghaus D., Dommisch H., Guezeldemir-Akcakanat E., ...More

Circulation. Cardiovascular genetics, vol.8, no.1, pp.159-67, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1161/circgenetics.114.000554
  • Journal Name: Circulation. Cardiovascular genetics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.159-67
  • Keywords: coronary artery disease, genetic association studies, periodontitis, plasminogen, GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCUS, TGF-BETA, ACTIVATION, ATHEROSCLEROSIS, INFLAMMATION, REPLICATION, 9P21.3, FORMS
  • Kocaeli University Affiliated: Yes

Abstract

Background-Genetic studies demonstrated the presence of risk alleles in the genes ANRIL and CAMTA1/VAMP3 that are shared between coronary artery disease (CAD) and periodontitis. We aimed to identify further shared genetic risk factors to better understand conjoint disease mechanisms.