Spinal cord compression and lung metastasis of Wilms' tumor in a pregnant adolescent.

Corapcioglu F., Dillioglugil Ö. , Sarper N. , Akansel G., Caliskan M., Arisoy A. E.

Urology, vol.64, no.4, pp.807-10, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1016/j.urology.2004.05.032
  • Title of Journal : Urology
  • Page Numbers: pp.807-10


Wilms' tumor in adults is rare, and no treatment guidelines have been established. Spinal cord compression has also been rarely reported in all age groups. In this case report, we present a 19-year-old adolescent with recurrent Wilms' tumor, a paraspinal dumbbell mass, metastatic involvement of the vertebral bodies, lung metastasis, and pregnancy. To our knowledge, this is the first report of a pregnant patient with Wilms' tumor who had to undergo immediate chemotherapy with vincristine and actinomycin-D owing to spinal cord compression at 25 weeks of pregnancy. After delivery, complete remission was maintained with a regimen of ifosfamide, carboplatin, and etoposide and vincristine, actinomycin-D, and cyclophosphamide. No teratogenic or other toxic effects of vincristine or actinomycin-D were observed in the fetus. (C) 2004 Elsevier Inc.