Akademik Veri Yönetim Sistemi
24th Biennial International Congress on Thrombosis / EMLTD Congress, İstanbul, Türkiye, 4 - 07 Mayıs 2016, cilt.141, (Özet Bildiri)
Background: Ischemia/reperfusion (I/R) during abdominal aorta surgeries leads to remote organ damage and the major part of this damage occurs upon reperfusion via oxygen free radicals. A novel direct factor Xa inhibitor, Rivaroxaban and an antiplatelet agent, Cilostazol are analyzed in this study for their protective effects on lung and renal tissues following abdominal aota ischemia/reperfusion model in rats.
Methods: Thirty-two male Spraque-Dawley rats were randomized as sham group (I/R, n=8), control group (n=8), and I/R+ Rivaroxaban (n=8, 20mg/ kg orally administered before ischemia) and I/R+Cilostazol (n=8, 100mg/ kg orally administered before ischemia) groups. Ischemia and reperfusion was induced by clamping the infrarenal aorta for 2 hours and declamping for reperfusion for 4 hours. Lung and renal tissue assays were performed for lipid peroxidation product malondealdehyde (MDA) and Glutathione Reductase (GR) and Glutathione Peroxidase (GPx) levels were also studied. Lung and renal tissues were also examined histopathologically under light microscopy.
Results: Both Rivaroxaban and Cilostazol attenuated lung and renal cell damages occurred by downregulating the level of MDA and upregulating the levels of GPX and GR. These results are confirmed also with the histopathological results.
Conclusions: These results suggested that one dose oral administration of both Rivaroxaban and Cilostazol effectively ameliorates the ischemia/ reperfusion induced oxidative damage of lung and renal tissues by virtue of
their antioxidant and anti-inflammatory potentials.