Effect of rosiglitazone on insulin resistance, C-reactive protein and endothelial function in non-obese young women with polycystic ovary symdrome

Tarkun, I; Cetinarslan, BERRİN; Turemen, E; Sahin, T; Canturk, Z; Komsuoglu, B

doi:10.1530/eje.1.01948

Effect of rosiglitazone on insulin resistance, C-reactive protein and endothelial function in non-obese young women with polycystic ovary symdrome

Tarkun I., Cetinarslan B., Turemen E., Sahin T., Canturk Z., Komsuoglu B.

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.153, sa.1, ss.115-121, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 153 Sayı: 1
Basım Tarihi: 2005
Doi Numarası: 10.1530/eje.1.01948
Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.115-121
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Women with polycystic ovary syndrome (PCOS) exhibit elevated levels of serum C-reactive protein (CRP) and impaired endothelium dysfunction which arc directly correlated with insulin resistance. Because rosiglitazone improves insulin sensitivity, we tested whether rosiglitazone treatment ameliorates high-sensitivity (hs)CRP levels and endothelial dysfunction in these patients.