Granulomatous Dermatitis Characterized by the Manifestation of Tumor and Plaque Lesions Subsequent to Herpes Zoster: A Case Series

BAYRAMGÜRLER D., DEMİRBAŞ A., Durdu M., ASLANKOÇ G. E., Eruyar T., Demirkesen C.

Dermatology Practical and Conceptual, vol.14, no.2, 2024 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2024
  • Doi Number: 10.5826/dpc.1402a129
  • Journal Name: Dermatology Practical and Conceptual
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Keywords: Granulomatous reaction, Postherpetic isotopic response, Tumor
  • Kocaeli University Affiliated: Yes


Wolf's isotopic response is a phenomenon where a healed skin condition reappears at the same site, causing a new condition. The cause is unknown, but it is suggested to be an immunosuppressed region [1-3]. This area becomes susceptible to infections, tumors, and immune disorders. Chronic lymphedema, herpetic infections, vaccinations, and physical injuries can damage the cutaneous site, making it vulnerable. The most common isotopic response is PHIR, which is characterized by papules or plaques, patchy or nodular lesions, and hyperpigmentation [1-4]. Most cases have immunosuppressive and hematological malignancies, and both cases have hematological malignancies [1-5]. Topical steroids are commonly used in treating PHIR-GD cases [1-5], but no case has been treated with intralesional steroids. In conclusion, PHIR-GD can cause tumoral lesions, and intralesional corticosteroid therapy can be used for tumor management.