Deregulated Levels of the NF-kappa B1, NF-kappa B2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period

SAVLI H., Akkoyunlu R. U., ÇİNE N., Gluzman D. F., Zavelevich M. P., Sklyarenko L. M., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.33, no.1, pp.8-14, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.4274/tjh.2014.0190
  • Journal Name: TURKISH JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.8-14
  • Kocaeli University Affiliated: Yes

Abstract

Objective: Nuclear factor kappa B (NF-kappa B) is an important transcription factor in cancer and NF-kappa B activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-kappa B gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-kappa B1, NF-kappa B2, and Rel genes in hematological malignancies in the post-Chernobyl period.