The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients

Albayrak C., TARKUN P., Atesoglu E. B., Eraldemir C., ÖZSOY Ö. D., Demirsoy E. T., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.49, sa.1, ss.74-80, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/sag-1803-13
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.74-80
  • Anahtar Kelimeler: Polycythemia vera, essential thrombocythemia, chronic myeloproliferative neoplasm, GDF15, hepcidin, mitoferrin-1, GROWTH-DIFFERENTIATION FACTOR-15, PROHEPCIDIN, EXPRESSION, MUTATIONS, ABCB10, JAK
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Background/aim: GDF15 hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There are no studies in the literature demonstrating the serum mfrn-1 levels in polycythemia vera (PV) and essential thrombocythemia (ET) patients. The aim of this study was to investigate GDF15, hepcidin and mfrn-1 levels in PV and FT patients.