The role of hepcidin, GDF15, and mitoferrin-1 in iron metabolism of polycythemia vera and essential thrombocytosis patients

Albayrak C., TARKUN P., Atesoglu E. B., Eraldemir C., ÖZSOY Ö. D., Demirsoy E. T., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.49, no.1, pp.74-80, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.3906/sag-1803-13
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.74-80
  • Keywords: Polycythemia vera, essential thrombocythemia, chronic myeloproliferative neoplasm, GDF15, hepcidin, mitoferrin-1, GROWTH-DIFFERENTIATION FACTOR-15, PROHEPCIDIN, EXPRESSION, MUTATIONS, ABCB10, JAK
  • Kocaeli University Affiliated: Yes

Abstract

Background/aim: GDF15 hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There are no studies in the literature demonstrating the serum mfrn-1 levels in polycythemia vera (PV) and essential thrombocythemia (ET) patients. The aim of this study was to investigate GDF15, hepcidin and mfrn-1 levels in PV and FT patients.