Increased reliability problems in deep sub-micron CMOS technologies have led to a dramatic decrease of lifetime of analog integrated circuits. To palliate this problem, several reliability-aware design approaches have been developed. Reconfigurable circuit design is one of those approaches, which is based on reconfiguring the circuit considering degradation in circuit performances. Sense & React (S & R) approach is the well-known reconfigurable design approach, where degradation in circuit performances are sensed and a pre-established recovery operation is applied to heal the circuit. In practice, indirect measurements are preferred during sense operation, in which electrical quantities are measured in order to determine time to recovery. Determination of the time to recover is the most critical part of a S & R system. One or more circuit variables are selected out of all measurable circuit quantities. The selected signature should have some attributes to be used as the aging signature to reduce the measurement cost. However, efficient aging signature properties have not been defined in the literature yet. Moreover, the designer determines the aging signature manually by performing an iterative search and evaluation on aging simulation results, and there is no tool to ease this time consuming process. This paper clearly describes the aging signature properties and proposes an automatic signature selection tool that determines the most efficient signature for sense operation.