Comparison of cytogenetic and molecular features observed in endometrial cancers: known clinic and difficulties in treatment Comparación de las características citogenéticas y moleculares observadas en los cánceres de endometrio: clínica conocida y dificultades en el tratamiento

Uzel K., KESKİN S. Ö., Bilir F., Gokbayrak M., Demir G., ÇİNE N., ...Daha Fazla

Cirugia y Cirujanos, cilt.93, sa.2, ss.138-144, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.24875/ciru.23000328
  • Dergi Adı: Cirugia y Cirujanos
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.138-144
  • Anahtar Kelimeler: Endometrial cancer, Genomics, Pathology, Prognostic factors, Targeted therapy
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Understanding the relationship between genetic structure and the molecular changes involved in endometrial cancer (EC) provides an opportunity to personalize treatments and incorporate targeted therapies. Method: We compared cytogenetic and molecular features observed in tumoral and adjacent healthy tissue endometrium samples in EC patients. Results: Non-clonal chromosome aberrations (NCCAs) frequently in patients with EC, especially in 10,15,17,22, X chromosomes and were monitored in 73.7%, clonal chromosomal alterations were observed in 26.3% of the patients. Down POLE gene expression in 42.1%, up p53gene expression in 57.9%, PTEN down-regulation in 47.3%, down ARID1A gene expression in 42.1%, PIK3CA up-regulation was observed in 68% of patients. Conclusion: The up-regulation of tumor suppressor genes in our study shows that not only these genes are involved but also different pathways and factors play a role in tumorigenesis. Furthermore, an increased number of NCCAs shows an essential role in the development of ECs.