Photoproperties, PVP formulation and <SUP>19</SUP>F NMR of a Zn phthalocyanine with 24 magnetically pseudo-equivalent fluorine atoms

Kucuk, Tugba; Alpugan, Serkan; Davarci, DERYA; Pehlivan, Eda; Bayir, Sumeyra; Tazebay, Uygar; DUMOULIN , FABIENNE

doi:10.1142/s1088424619500512

Photoproperties, PVP formulation and <SUP>19</SUP>F NMR of a Zn phthalocyanine with 24 magnetically pseudo-equivalent fluorine atoms

Kucuk T., Alpugan S., Davarci D., Pehlivan E. G., Bayir S., Tazebay U. H., ...Daha Fazla

JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, cilt.23, sa.4-5, ss.611-618, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 4-5
Basım Tarihi: 2019
Doi Numarası: 10.1142/s1088424619500512
Dergi Adı: JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.611-618
Kocaeli Üniversitesi Adresli: Hayır

Özet

In an attempt to investigate its potential as a PDT F-19 MRI molecular theranostic, a Zn phthalocyanine with 24 pseudo-equivalent fluorine atoms was designed and prepared. Compared to its H analogues, the fluorinated derivative has a much higher generation of singlet oxygen. F-19 NMR signals in CDCl3 showed that all the fluorine atoms are magnetically pseudo-equivalent with only two close fluorine signals. Formulation in PVP (polyvinylpyrrolidone), a FDA-approved additive, enabled water-solubilization of the phthalocyanines but no satisfying F-19 NMR signal could be obtained, probably due to self-quenching caused by aggregation.