Are Patients With Diabetes Mellitus at Increased Risk of COVID-19 Infection?

Sözen M., Çölkesen F., Arslan Ş., Çölkesen F., Karaköse M., Erayman İ., ...Daha Fazla

Archives of Current Medical Research, cilt.1, sa.2, ss.38-44, 2021 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.47482/acmr.2021.13
  • Dergi Adı: Archives of Current Medical Research
  • Derginin Tarandığı İndeksler: MEDLINE, Index Copernicus, Asos İndeks
  • Sayfa Sayıları: ss.38-44
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Abstract

Background: The aim of this study was to examine the clinical course and outcomes of patients with diabetes mellitus (DM) with

coronavirus disease-2019 (COVID-19).

Methods: This retrospective, single-center study included 185 adult patients diagnosed with COVID-19. All patients were

separated into 4 groups. Group 1(n=79): patients with no accompanying disease, Group 2 (n=14): patients with only DM, Group

3 (n=31): patients with comorbid disease(s) including DM, Group 4 (n=61): patients with comorbid disease(s) without DM. Data

about COVID-19 management and outcome were obtained from the medical records of the patients. COVID-19 was confirmed by

real-time polymerase chain reaction (RT-PCR) from throat swab samples. All patients underwent chest x-rays or chest computed

tomography.

Results: 185 patients diagnosed with COVID-19 were evaluated. The COVID-19 prognoses of the patients were classified as good,

moderate and poor. No statistically significant difference was determined between the groups in terms of COVID-19 prognosis

(p>0.05). While the rate of DM patients with a good prognosis was 20.4%, the DM patient rate increased up to 40% among moderate

or poor prognosis patients. A statistically significant difference was observed between blood glucose levels and mortality (p:

0.008). Mortality due to COVID-19 pneumonia developed in 15 (8.1%) patients. Mortality increase was mostly encountered in the

group with DM and accompanying comorbidities. It was observed that ACEI / ARB use had no effect on mortality.

Conclusions: Although the study results do not show a statistically significant effect of DM on the prognosis of COVID-19 patients,

the higher rate of DM patients in the group with poor prognosis suggests that it may affect the severity of COVID-19. These results

may be useful for clinicians in the management of DM patients with COVID-19.