Genetic alterations in human prostate cancer: A review of current literature

Ozen M., Pathak S.

ANTICANCER RESEARCH, cilt.20, sa.3B, ss.1905-1912, 2000 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 20 Sayı: 3B
  • Basım Tarihi: 2000
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1905-1912
  • Anahtar Kelimeler: prostate cancer genetics, telomere, tumor suppressor genes, proto-oncogenes, malignant transformation, TUMOR-SUPPRESSOR GENE, IN-SITU HYBRIDIZATION, GROWTH-FACTOR-BETA, FAMILIAL ADENOMATOUS POLYPOSIS, P53 PROTEIN ACCUMULATION, TELOMERE LENGTH, SOMATIC MUTATIONS, CARCINOMA-CELLS, DNA-PLOIDY, CHROMOSOMAL INSTABILITY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

We review the literature dealing with genetic alterations in human prostate cancer. We also discuss genetic predisposition and the roles of various proto-oncogenes and tumor-suppressor genes in prostate cancer initiation, progression, and metastasis. The role of telomere dynamics in prostate cancer metastasis and the induction of apoptosis is also briefly discussed.