An unusual hydroboration of 3-hydroxy-3-methyl-Delta(4)-steroids


Uyanik C. , Hanson J., Nisius L., Hitchcock P.

JOURNAL OF CHEMICAL RESEARCH, no.7, pp.471-473, 2004 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: Issue: 7
  • Publication Date: 2004
  • Title of Journal : JOURNAL OF CHEMICAL RESEARCH
  • Page Numbers: pp.471-473
  • Keywords: steroids, hydroboration, X-ray crystallography, ALCOHOLS

Abstract

Hydroboration of 3-hydroxy-3-methyl-Delta(4)-steroids, and oxidation of the borane with alkaline hydrogen peroxide, has been shown by X-ray crystallography to give 4beta-hydroxy-3alpha-methyl-5beta(H)-steroids irrespective of the stereochemistry at C-3.