An unusual hydroboration of 3-hydroxy-3-methyl-Delta(4)-steroids


Uyanik C., Hanson J., Nisius L., Hitchcock P.

JOURNAL OF CHEMICAL RESEARCH, no.7, pp.471-473, 2004 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: Issue: 7
  • Publication Date: 2004
  • Journal Name: JOURNAL OF CHEMICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.471-473
  • Keywords: steroids, hydroboration, X-ray crystallography, ALCOHOLS
  • Kocaeli University Affiliated: Yes

Abstract

Hydroboration of 3-hydroxy-3-methyl-Delta(4)-steroids, and oxidation of the borane with alkaline hydrogen peroxide, has been shown by X-ray crystallography to give 4beta-hydroxy-3alpha-methyl-5beta(H)-steroids irrespective of the stereochemistry at C-3.