Apolipoprotein E phylogeny and evolution
CELL BIOCHEMISTRY AND FUNCTION, cilt.26, ss.43-50, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26
- Basım Tarihi: 2008
- Doi Numarası: 10.1002/cbf.1396
- Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.43-50
- Anahtar Kelimeler: apolipoprotein E, phylogeny, evolution, diet, SEQUENCE ALIGNMENT, TERMINAL DOMAIN, PROTEIN, FAMILY
- Kocaeli Üniversitesi Adresli: Evet
Özet
Among apolipoproteins, apolipoprotein E (Apo E) plays a pivotal role in lipid transport and is proposed to be involved in neural repair. Because of a long divergence history of apolipoproteins, it is unclear how Apo E evolved in time. To investigate relationships among Apo E proteins, we used the information from molecular data and analysed the phylogeny of Apo E proteins from various species. Several phylogenctic trees were generated by using both character-based and distance-based phylogenetic methods. Apo E sequences of fish and frog were found to be less related to the Apo E sequences of other species. The most likely ancestor of Apo E among 18 organisms was estimated to be the Apo E of frog. Members of the groups formed by the Apo E proteins of various species shared similar feeding habits and diet. It may be suggested that Apo E evolution and very likely the evolution of other apolipoproteins are influenced by the organism's feeding environment and diet. Copyright (C) 2007 John Wiley & Sons, Ltd.