Cytotoxic lesions of the corpus callosum in children: Etiology, clinical and radiological features, and prognosis

Uzunhan T. A., Genc H. M., Kutlubay B., Kalin S., Bektas G., Yapici O., ...More

BRAIN & DEVELOPMENT, vol.43, no.9, pp.919-930, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.1016/j.braindev.2021.05.001
  • Journal Name: BRAIN & DEVELOPMENT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.919-930
  • Keywords: Apparent life-threatening event (ALTE), COVID-19, Cytotoxic lesions of the corpus callosum (CLOCCs), Diffusion-weighted magnetic resonance imaging (MRI), Epilepsy, Mild encephalitis/encephalopathy with reversible splenial lesion (MERS), Reversible splenial lesion syndrome (RESLES), Saposin B deficiency, Urea cycle defect, REVERSIBLE SPLENIAL LESION, MILD ENCEPHALITIS/ENCEPHALOPATHY, ENCEPHALOPATHY
  • Kocaeli University Affiliated: Yes


Objectives: Cytotoxic lesions of the corpus callosum (CLOCCs) are secondary lesions associated with entities like infection manifested by restricted diffusion on diffusion-weighted cranial magnetic resonance imaging. Our objectives are to evaluate the clinic-radiological spectrum of pediatric patients with cytotoxic lesions of the corpus callosum (CC).