Kidney Functions and Obstetric Outcome of Pregnancies After Kidney Transplantation
Turkish Journal of Nephrology, cilt.35, sa.2, ss.136-145, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.5152/turkjnephrol.2025.24816
- Dergi Adı: Turkish Journal of Nephrology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.136-145
- Anahtar Kelimeler: Allograft function, kidney transplantation, preeclampsia, pregnancy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Kocaeli Üniversitesi Adresli: Evet
Özet
Background: This study aims to assess the clinical course and pregnancy outcomes after kidney transplantation and investigate the function of kidney grafts. Methods: This retrospective cohort analysis included 17 pregnancies in 14 patients with a history of kidney transplantation, who were followed up at a single tertiary hospital. Sociodemographic data, medical history, obstetric data, and laboratory parameters in each trimester, as well as before, within 24 hours, and 6 months after delivery, were collected. Results: Among the 17 pregnancies, 1 patient had an abortion, 1 had dilatation and curettage, and 3 had 2 pregnancies during the study period. One woman had a twin pregnancy. The median serum creatinine concentration before conception was 0.8 (0.8-0.9) mg/dL. The median time interval between kidney transplantation and pregnancy was 78 months (interquartile range: 42-138 months). Serum creatinine levels were higher and estimated glomerular filtration rates were lower in the third trimester than in the pre-pregnancy, first, and second trimesters. The urinary protein-to-creatinine ratio was higher in the third trimester. None of the patients experienced graft rejection during pregnancy. Fourteen pregnancies resulted in live births; 8 patients had preeclampsia (53%); 11 neonates were born prematurely (73%); and 8 of the babies were small for gestational age (53%). Conclusion: The short-term impact of pregnancy on allograft function appears to be acceptable despite a statistically significant increase in serum creatinine levels during the third trimester. However, close surveillance is mandatory in pregnancies after kidney transplantation, because it confers a greater risk of obstetric complications.