Quantum chemical calculations, Hirshfeld surface analysis, and molecular docking studies of antibacterial (E)-N '-((1H-Indol-3-yl)methylene)-4-bromobenzohydrazide


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Eşme A.

SPECTROSCOPY LETTERS, cilt.52, ss.398-412, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 52 Konu: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/00387010.2019.1651339
  • Dergi Adı: SPECTROSCOPY LETTERS
  • Sayfa Sayısı: ss.398-412

Özet

The theoretical parameters such as optimized geometrical parameters (bond lengths, bond angles, and dihedral angles), vibrational assignments, non-linear optical property, natural population analysis, and global chemical descriptors were calculated using the density functional theory with Becke, 3-parameter, Lee-Yang-Parr functional and Coulomb-attenuating method. Spectroscopic characterization of (E)-N '-((1H-Indol-3-yl)methylene)-4-bromobenzohydrazide was investigated by the Fourier transform infrared analysis with the potential energy distribution, proton nuclear magnetic resonance, and ultraviolet-visible techniques. The intermolecular interactions of the title molecule in the crystal structure were visualized by the three-dimensional Hirshfeld surface and associated two-dimensional fingerprint plots. In order to understand molecular stability, global reactive properties calculated at the time-dependent density functional theory have been investigated by visualization of frontier molecular orbitals. In addition, the first-order hyperpolarizability has been investigated to understand the non-linear optical activity of the molecule. Molecular docking studies supporting the antibacterial activity of the title molecule give a high-binding energy value of -5.20 kcal/mol due to the interaction of the carbonyl group with the target protein.