Congenital Self-Healing Reticulohistiocytosis Presenting at Birth: Clinicopathologic Features of a Rare Neonatal Case Konjenital Kendiliğinden İyileşen Retikülohistiyositoz: Nadir Bir Yenidoğan Olgunun Klinikopatolojik Özellikleri
Turkiye Klinikleri Dermatoloji, vol.36, no.1, pp.43-46, 2026 (Scopus)
- Publication Type: Article / Article
- Volume: 36 Issue: 1
- Publication Date: 2026
- Doi Number: 10.5336/dermato.2025-111195
- Journal Name: Turkiye Klinikleri Dermatoloji
- Journal Indexes: Scopus, EMBASE
- Page Numbers: pp.43-46
- Keywords: congenital, Hashimoto-Pritzker disease, histiocytosis, Langerhans-cell, newborn, remission
- Open Archive Collection: AVESIS Open Access Collection
- Kocaeli University Affiliated: Yes
Abstract
Congenital self-healing reticulohistiocytosis is a rare cutaneous form of Langerhans cell histiocytosis that typically manifests in neonates and resolves spontaneously without systemic involvement. We present a case of a male infant who developed multiple papulovesicular skin lesions 2 days after birth. Histopathological examination showed CD1a and S100 positivity, confirming Langerhans cell histiocytosis. The lesions regressed without treatment within 1 month, and no recurrence or systemic involvement was observed during 1.5 years of follow-up. This case underlines the importance of considering congenital self-healing reticulohistiocytosis in neonates presenting with spontaneously regressing skin lesions and highlights the necessity of careful long-term monitoring due to the risk of late systemic involvement or relapse. Awareness of this self-limiting condition can prevent unnecessary interventions and their associated risks.