The protective effect of metformin in scopolamine-induced learning and memory impairment in rats

Aksoz E., Gocmez S. S. , Demirtaş Şahin T. , Aksit D., Aksit H., Utkan T.

PHARMACOLOGICAL REPORTS, vol.71, pp.818-825, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71
  • Publication Date: 2019
  • Doi Number: 10.1016/j.pharep.2019.04.015
  • Page Numbers: pp.818-825


Background: Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. One of the most commonly prescribed oral antidiabetic drug, metformin, has been shown to have beneficial effects on restoring impaired cognitive function. In the present study, we investigated the effects of metformin on spatial memory in terms of alleviating scopolamine-induced learning and memory impairments in rats by using the Morris water maze (MWM) test and the modified elevated plus-maze (mEPM) test. Furthermore, we investigated the possible mechanisms of action of metformin in preventing cognitive dysfunction.