Synthesis, Anticancer Evaluation and Pharmacokinetic Studies of Quinoline-Triazole Hybrid Derivatives

Kulu I.

ChemistrySelect, vol.7, no.39, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 39
  • Publication Date: 2022
  • Doi Number: 10.1002/slct.202202783
  • Journal Name: ChemistrySelect
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Keywords: Quinoline, 1, 2, 3-Triazole, Anti-cancer, T24 cell, Global Reactivity, 1,2,3-TRIAZOLES, FREQUENCY
  • Kocaeli University Affiliated: No


© 2022 Wiley-VCH GmbH.Synthesis of effective and target-selective biologically active molecules through conjugation of diversely substituted triazoles and 5-aminoquinoline was achieved successfully with 1,4-disubstituted regioisomer products in the 3+2 cycloaddition reaction, as expected. Seven quinoline-1,2,3-triazole hybrid compounds which bear different substituent groups were subjected to FTIR, 1HNMR, 13CNMR and MALDI-MS spectroscopic characterization methods. All quinoline-1,2,3-triazole hybrid derivatives (8 a–g) were explored for their anti-cancer activity towards Human urinary bladder carcinoma (T24) cells through cell viability, fluorescent imaging and colony formation analyses. Some chemical reactivity potentials and the pharmacokinetic properties of the quinoline-1,2,3-triazole hybrid compounds were analyzed. The frontier molecular orbital energies gap and chemical behaviour indices based on HOMO and LUMO energy values were analyzed via in-silico methods. All in vitro and in silico results are in agreement that quinoline-triazole derivative 8 f has potent anticancer activity and could serve for further investigation to enhance its potential biological activities.