Cyclotriphosphazene, a scaffold for <SUP>19</SUP>F MRI contrast agents

Onal, Emel; Zhang, Cheng; Davarci, DERYA; İŞCİ, ÜMİT; Pilet, Guillaume; Whittaker, Andrew; DUMOULIN , FABIENNE

doi:10.1016/j.tetlet.2017.12.032

Cyclotriphosphazene, a scaffold for <SUP>19</SUP>F MRI contrast agents

Onal E., Zhang C., Davarci D., İŞCİ Ü., Pilet G., Whittaker A. K., ...Daha Fazla

TETRAHEDRON LETTERS, cilt.59, sa.6, ss.521-523, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 59 Sayı: 6
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.tetlet.2017.12.032
Dergi Adı: TETRAHEDRON LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
Sayfa Sayıları: ss.521-523
Kocaeli Üniversitesi Adresli: Hayır

Özet

A cyclotriphosphazene substituted with six 3,5-bis(trifluoromethyl) benzyloxy units was designed as a novel F-19 MRI contrast agent. The resulting molecule has 36 magnetically equivalent fluorine atoms and exhibited suitable MRI properties with high imaging sensitivity, confirming the proof-of-concept as a convenient scaffold for the production of new F-19 MRI contrasts agents. (C) 2017 Elsevier Ltd. All rights reserved.