A PRELIMINARY STUDY: COMPARATIVE PROTEOMIC PROFILING OF BREAST CANCER TISSUE AND METASTATIC AXILLARY LYMPH NODE

Akpinar G., Simsek T., Kasap M., CANTÜRK N. Z.

JOURNAL OF BREAST HEALTH, cilt.9, sa.2, ss.64-68, 2013 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5152/tjbh.2013.06
  • Dergi Adı: JOURNAL OF BREAST HEALTH
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.64-68
  • Anahtar Kelimeler: Breast cancer, axillary, lymph node, 2D-PAGE, proteomics, CARCINOMA, PREDICT
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Objective: Breast cancer remains one of the most common malignancies affecting women. In breast cancer, axillary lymph node (ALN) involvement is a useful clinical parameter for decision-making. Although ALN dissection is associated with upper extremity lymphoedema and other morbidities, the presence of ALN metastasis is the most important prognostic factor predicting breast cancer patient survival. The prediction of ALN metastasis by evaluating expression of tumor-related proteins of primary breast cancer is potentially a promising approach because the primary tumor is readily assessed.