Effects of Nebivolol on Skin Flap Survival: A Randomized Experimental Study in Rats

Gideroglu K., Alagoz S., Uygur F., Evinc R., Celikoz B., BUĞDAYCI G.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.69, no.5, pp.449-458, 2008 (Journal Indexed in SCI) identifier identifier


BACKGROUND: Skin flaps are among the basic treatment options in the reconstruction of soft tissue defects. To improve skin flap survival, a variety of methods, including pharmacologic agents, have been investigated. The effectiveness of anticoagulants, antioxidants, anti-inflammatory drugs, and vasodilatory drugs in improving flap survival has been studied. Nebivolol isa new-generation selective beta(1)-adrenoreceptor blocking agent that has vasodilatory, antithrombotic, antioxidative, and anti-inflammatory effects.