Effects of Nebivolol on Skin Flap Survival: A Randomized Experimental Study in Rats


Gideroglu K., Alagoz S., Uygur F., Evinc R., Celikoz B., BUĞDAYCI G.

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, vol.69, pp.449-458, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.1016/j.curtheres.2008.10.001
  • Title of Journal : CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
  • Page Numbers: pp.449-458

Abstract

BACKGROUND: Skin flaps are among the basic treatment options in the reconstruction of soft tissue defects. To improve skin flap survival, a variety of methods, including pharmacologic agents, have been investigated. The effectiveness of anticoagulants, antioxidants, anti-inflammatory drugs, and vasodilatory drugs in improving flap survival has been studied. Nebivolol isa new-generation selective beta(1)-adrenoreceptor blocking agent that has vasodilatory, antithrombotic, antioxidative, and anti-inflammatory effects.