Droplet-based microfluidics in biomedical applications

Amirifar L., Besanjideh M., Nasiri R., Shamloo A., Nasrollahi F., De Barros N. R., ...Daha Fazla

BIOFABRICATION, cilt.14, sa.2, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1088/1758-5090/ac39a9
  • Dergi Adı: BIOFABRICATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Compendex, EMBASE, INSPEC, MEDLINE
  • Anahtar Kelimeler: microfluidics, droplet, drug delivery, detection, particle synthesis, diagnostics, cell, POLYMERASE-CHAIN-REACTION, PROTEIN-PROTEIN INTERACTIONS, DRUG-DELIVERY PLATFORM, DIGITAL PCR, T-JUNCTION, SERPENTINE MICROCHANNELS, MULTICELLULAR SPHEROIDS, HYDROGEL MICROCAPSULES, EMULSIFICATION DEVICE, SENSITIVE DETECTION
  • Kocaeli Üniversitesi Adresli: Evet

Özet

Droplet-based microfluidic systems have been employed to manipulate discrete fluid volumes with immiscible phases. Creating the fluid droplets at microscale has led to a paradigm shift in mixing, sorting, encapsulation, sensing, and designing high throughput devices for biomedical applications. Droplet microfluidics has opened many opportunities in microparticle synthesis, molecular detection, diagnostics, drug delivery, and cell biology. In the present review, we first introduce standard methods for droplet generation (i.e. passive and active methods) and discuss the latest examples of emulsification and particle synthesis approaches enabled by microfluidic platforms. Then, the applications of droplet-based microfluidics in different biomedical applications are detailed. Finally, a general overview of the latest trends along with the perspectives and future potentials in the field are provided.