A new and convenient synthesis of some substituted thiohydantoins


Durust Y., Nohut F.

SYNTHETIC COMMUNICATIONS, vol.29, pp.1997-2005, 1999 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 11
  • Publication Date: 1999
  • Doi Number: 10.1080/00397919908086188
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.1997-2005

Abstract

3-Substituted thiohydantoins (2a-g) were synthesized in satisfactory yields by the reaction of N-substituted thioureas (1a-g) with chloroacetylchloride in the presence of triethylamine under reflux in dioxane. S-Alkylated products (7, 8) were! obtained from the reaction of 3-p-tolyl -thiohydantoin (2d) with p-nitrobenzylchloride and 3-phenyl-5-chloromethyl-1,2,4-oxadiazole.