In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury

Unal, Cigdem; Sen, Cenk; Iscen, Deniz; Dalcik, Hakki

doi:10.1016/j.jss.2006.05.019

In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury

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Unal C., Sen C., Iscen D., Dalcik H.

JOURNAL OF SURGICAL RESEARCH, vol.138, no.2, pp.259-266, 2007 (SCI-Expanded)

Publication Type: Article / Article
Volume: 138 Issue: 2
Publication Date: 2007
Doi Number: 10.1016/j.jss.2006.05.019
Journal Name: JOURNAL OF SURGICAL RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.259-266
Kocaeli University Affiliated: No

Abstract

Objective. Ischemia reperfusion injury can cause failure in microsurgical operations. Interaction between leukocytes and endothelium is recognized as an integral step in ischemia reperfusion injury. Pentoxifylline is a methylxanthine derivative that has pharmacological properties that can be beneficial in ischemia reperfusion injury. The aim of this study was to investigate the in vivo effect of pentoxifylline on leukocyte-endothelium interaction in ischemia reperfusion injury.