In vivo observation of leukocyte-endothelium interaction in ischemia reperfusion injury with the dorsal window chamber and the effects of pentoxifylline on reperfusion injury


Unal C., Sen C., Iscen D., Dalcik H.

JOURNAL OF SURGICAL RESEARCH, cilt.138, ss.259-266, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 138 Konu: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.jss.2006.05.019
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayısı: ss.259-266

Özet

Objective. Ischemia reperfusion injury can cause failure in microsurgical operations. Interaction between leukocytes and endothelium is recognized as an integral step in ischemia reperfusion injury. Pentoxifylline is a methylxanthine derivative that has pharmacological properties that can be beneficial in ischemia reperfusion injury. The aim of this study was to investigate the in vivo effect of pentoxifylline on leukocyte-endothelium interaction in ischemia reperfusion injury.