Investigation of subclinical atherosclerosis in psoriatic arthritis patients with minimal disease activity

YILMAZER B., ŞAHİN T., Unlu B., Kir H., ÇEFLE A.

RHEUMATOLOGY INTERNATIONAL, cilt.35, sa.8, ss.1385-1392, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00296-015-3228-y
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1385-1392
  • Anahtar Kelimeler: Asymmetric dimethylarginine, Endothelial dysfunction, Psoriatic arthritis, Subclinical atherosclerosis, EVIDENT CARDIOVASCULAR-DISEASE, INTIMA-MEDIA THICKNESS, CORONARY FLOW RESERVE, ENDOTHELIAL DYSFUNCTION, RHEUMATOID-ARTHRITIS, CAROTID ATHEROSCLEROSIS, EUROPEAN-SOCIETY, WORKING GROUP, RISK-FACTORS, MORTALITY
  • Kocaeli Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the presence of subclinical atherosclerosis among psoriatic arthritis (PsA) patients without any cardiovascular disease (CVD) or traditional cardiovascular risk factors through measurement of endothelial function and carotid intima-media thickness (IMT) and correlated with disease-related risk factors. Twenty patients with PsA according to classification criteria for psoriatic arthritis and 20 age- and sex-matched controls were included. Patients with risk factors for cardiovascular disease were excluded. Carotid IMT was measured using two-dimensional carotid ultrasonography (USG). Endothelial function was determined by measuring flow-mediated endothelial-dependent vasodilatation (FMD %) and nitrate-induced dilatation (NID %) using brachial artery USG. Additionally, serum asymmetric dimethylarginine (ADMA) level was obtained using ELISA methodology. In this cross-sectional study, FMD % was significantly more decreased among PsA patients versus control group [mean 11 % (median (range) %10.5 (8-15 %)] and mean 13.2 % [median (range) 12, 8 % (8.1-17.6 %), respectively; p = 0.01]. There was no significant difference in NID %, ADMA level and mean IMT or maximum IMT results. FMD % did not show a significant correlation with clinical and laboratory data of PsA patients. This study showed that endothelial dysfunction may be present in PsA patients with no CVD and traditional cardiovascular risk factors. The study findings lend support to the previous reports that suggested a potential relationship between PsA and atherosclerotic disorders.